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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPsychological & BehavioralAnyone else feel guilty for using a drug to lose weight? — looking for input Page 2

Anyone else feel guilty for using a drug to lose weight? — looking for input

FranDenver Mon, Nov 24, 2025 at 9:59 PM 14 replies 1,143 viewsPage 2 of 3
JennaRN
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Nov 25, 2025 at 4:40 PM#6
PharmacoVig_BOS said:
Therapy insights from my mental health journey: my therapist introduced me to the concept of "identity updating" — the psychological work of becoming…

This is where I part company with the consensus forming above. I would be careful about how confidently the flatness reports get attributed. Rapid weight loss, a large deficit and disrupted sleep produce low mood on their own, and separating that from a drug effect is genuinely hard.

50 20Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 47 others
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DanielChem_CHI
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Nov 26, 2025 at 12:06 AM#7
FranDenver said:
My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer…

Before/after narrative for mental health — one year in:

Before (297 lbs): Winded climbing stairs, chronic back pain, pre-diabetic, on 3 medications, dreaded mirrors, avoided photos, social anxiety about my weight.

After (192 lbs): Run 3 miles regularly, pain-free, A1C normal, down to 1 medication, bought a swimsuit for the first time in a decade, actually enjoy being photographed.

Total weight lost: 97 lbs. Total life gained: immeasurable. This isn't just about weight — it's about reclaiming your identity.

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Dr.NateNeph
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Nov 26, 2025 at 7:32 AM#8
JennaRN said:
I would be careful about how confidently the flatness reports get attributed.

Mood changes on mental health: I want to be transparent — I went through a rough patch emotionally around month 2. Not depression exactly, but a weird flatness. Food was my main coping mechanism and without that, I had to develop new ones.

Therapy has been essential. I'd strongly recommend anyone starting GLP-1 therapy also invest in mental health support. The physical transformation is only half the journey.

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BiostatsBrad
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Nov 26, 2025 at 2:58 PM#9

A narrower follow-up, since the general answer is now clear:

What did you change at the same time, and can you separate the two now?

Last edited: Nov 26, 2025 at 3:58 PM
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FranDenver
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Nov 28, 2025 at 2:39 AM#10

OP back with an update, since a thread like this is useless without one.

Follow-up — I put something in the gap where food used to be rather than waiting for the gap to close on its own. That was the part nobody told me.

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