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ForumsPublic SquareGLP-1 and dental health — dry mouth, TMJ, and oral microbiome Page 3

GLP-1 and dental health — dry mouth, TMJ, and oral microbiome

Dr.GastroMayo Sat, Feb 28, 2026 at 2:15 PM 12 replies 846 viewsPage 3 of 3
kate.chem
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Mar 1, 2026 at 1:17 PM#11
JenPlateau said:
Forest plot interpretation for the the trial evidence meta-analysis: when reading the pooled estimate, pay attention to: Point estimate (HR/RR/OR) —…

No disagreement, though the timescale matters more than the mechanism here. Most of what looks like a difference in kind turns out to be a difference in how long somebody waited.

32 5steve_okc, dave_SLC, FDA_TrackerJim and 29 others
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ChrisMacros
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Mar 2, 2026 at 3:27 AM#12
Dr.LipidDallas said:
Dr.RenalNash said: ...regarding the trial evidence...

That reframing is the part I needed. Printing the relevant bit and taking it with me.

33 6TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 30 others
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LarryQC_SD
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Mar 2, 2026 at 5:37 PM#13
JenPlateau said:
Forest plot interpretation for the the trial evidence meta-analysis: when reading the pooled estimate, pay attention to: Point estimate (HR/RR/OR) —…

I read this differently from JenPlateau, on substance rather than tone. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.

34 7TinaHashiRN, robert_kc, dan_philly and 31 others
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PeptideSynthNJ
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Mar 3, 2026 at 7:47 AM#14

The figures, for anyone assembling their own picture. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

35 8MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 32 others
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mike_mod
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Mar 3, 2026 at 9:56 PM#15

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part.

36 9PurityPaulOR, MaxMetOK, MounjBrad and 33 others
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