Has anyone dealt with rybelsus real-world vs clinical trial efficacy?

NurseAsh_DET said:

Oral semaglutide is absorbed in the stomach with the help of SNAC, which locally raises pH and protects the peptide long enough to cross.

Thank you for spelling out the reasoning rather than just the conclusion. Printing the relevant bit and taking it with me.

Adding the clinical framing, because it changes how the question reads. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

I would rather be corrected than agreed with, if it comes to it.

LindaRN_retired said:

The gap between trial results and real-world results is consistent and it is not fraud.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I would add the less popular caveat: these trial populations under-represented several groups, older adults and the highest BMI categories among them. The results probably generalise, and "probably" should be stated as an assumption rather than dropped.

The figures, for anyone assembling their own picture. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.

That is the short version; the long version is somebody else's post.

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. Carry on.