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ForumsPsychological & BehavioralADHD and GLP-1 — need advice

ADHD and GLP-1 — need advice

pete_manc_UK Fri, Jan 9, 2026 at 4:54 PM 40 replies 1,456 viewsPage 1 of 8
pete_manc_UK
Senior Member
1,234
5,678
Mar 2024
Manchester, UK
Jan 9, 2026 at 4:54 PM#1

My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer have my main coping mechanism.

What I am trying to establish is how people separated a drug effect from the ordinary consequences of a large deficit and disrupted sleep, because I cannot.

If the honest answer is that nobody knows, that is a useful answer and I would rather have it.

5 0TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 2 others
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KevinCompounds
VIP Member
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Dec 2023
Nevada
Jan 9, 2026 at 6:21 PM#2
pete_manc_UK said:
My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer…
pete_manc_UK said:
...mental health should only be used alongside therapy...

I'd say therapy should be AVAILABLE to all GLP-1 patients, but requiring it as a precondition for treatment would create an access barrier.

Not everyone can afford therapy. Not everyone needs it. Some people do just fine with medication + lifestyle changes. But for those with emotional eating, body image issues, or disordered eating history, therapy is extremely valuable.

My recommendation: make mental health screening part of the initial assessment, offer therapy as a recommended adjunct, but don't gatekeep medication access behind it.

Last edited: Jan 9, 2026 at 8:21 PM
4 24Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 1 other
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pam_stl
Member
267
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Oct 2024
St. Louis, MO
Jan 9, 2026 at 7:48 PM#3
KevinCompounds said:
pete_manc_UK said: ...mental health should only be used alongside therapy...

When to call your doctor about mental health side effects — a reference I wish I'd had:

Call immediately:

  • Severe abdominal pain (could be pancreatitis)
  • Vision changes (thyroid concern)
  • Lump in neck (thyroid nodule)
  • Severe vomiting/can't keep fluids down for 24h+

Schedule an appointment:

  • Persistent nausea beyond 4 weeks
  • Significant hair loss
  • Mood changes or depression
  • Gallbladder symptoms (RUQ pain after eating)
Last edited: Jan 10, 2026 at 12:48 AM
3 23PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC
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VanRx_Mike
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Jan 9, 2026 at 9:15 PM#4
pete_manc_UK said:
My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer…

Same experience, arrived at from the opposite direction.

Last edited: Jan 10, 2026 at 12:15 AM
2 22Dr.Martinez, mike_mod
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sarah_TO
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Sep 2024
Toronto, CA
Jan 10, 2026 at 5:41 AM#5

From the other side of the consultation, briefly.

Mood changes on mental health: I want to be transparent — I went through a rough patch emotionally around month 3. Not depression exactly, but a weird flatness. Food was my main coping mechanism and without that, I had to develop new ones.

Therapy has been essential. I'd strongly recommend anyone starting GLP-1 therapy also invest in mental health support. The physical transformation is only half the journey.

Last edited: Jan 10, 2026 at 9:41 AM
1 21DanielChem_CHI
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