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ForumsPublic SquareGLP-1 therapy in patients over 65 — safety and efficacy data Page 8

GLP-1 therapy in patients over 65 — safety and efficacy data

GraceAZ_72 Sun, Apr 5, 2026 at 11:59 AM 40 replies 1,293 viewsPage 8 of 8
maria_elpaso
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Apr 28, 2026 at 3:24 AM#36

One thing that is still open after james_edin’s answer:

How would you tell the difference between that and the alternative explanation?

4 2FitDadDave, RunnerRach, TrialNerd_Beth and 1 other
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Dr.SleepRoch
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Apr 29, 2026 at 7:17 AM#37
DoseLogDan said:
Say what you would expect to see if you were wrong, before you look.

Pushing back on DoseLogDan here. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

5 3kim_atl_prep, sarah_TO, wendy_avl and 2 others
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nick_newbie
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Apr 30, 2026 at 11:10 AM#38
DoseLogDan said:
Say what you would expect to see if you were wrong, before you look.

Agreed on the substance. I would put less weight on the timescale, because two months of anything is not enough to distinguish a trend from a wobble.

Happy to go further on any of that.

6 4MeganSA_TX, LarryQC_SD, wanda_boise and 3 others
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BiostatsBrad
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May 1, 2026 at 3:04 PM#39
DoseLogDan said:
Say what you would expect to see if you were wrong, before you look.

That reframing is the part I needed. Sending this to two other people who asked me the same thing last week.

Last edited: May 1, 2026 at 4:04 PM
7 5james_edin, FranDenver, Dr.BariatricHTX and 4 others
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pete_nash
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Nashville, TN
May 2, 2026 at 6:59 PM#40

Adding the clinical framing, because it changes how the question reads. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

29 2sarah.morrison, NeuroNate, JessicaH_TX and 26 others
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