The GLP Lounge Community Rules — Updated January 2026
Public Square is a small room with a long memory. These are the house rules; they are short because we would rather enforce a few things properly than list twenty and mean none of them.
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Admin said:The GLP Lounge Community Rules — Updated January 2026 Public Square is a small room with a long memory.
Agreed, and subgroup analyses deserve particular suspicion. With enough subgroups something is significant by chance, and pre-registered subgroups are a different animal from ones found afterwards.
Admin said:The GLP Lounge Community Rules — Updated January 2026 Public Square is a small room with a long memory.
This is where I part company with the consensus forming above. I would add the less popular caveat: these trial populations under-represented several groups, older adults and the highest BMI categories among them. The results probably generalise, and "probably" should be stated as an assumption rather than dropped.
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View ResultsThis one has a reasonably settled answer, so here it is. Read four things before the headline number. The population, because trial populations are selected and supported in ways that real cohorts are not. The comparator, because "better than placebo" and "better than the current standard" are different claims and get reported identically. The primary endpoint as pre-registered, because a secondary endpoint promoted after the fact is a hypothesis rather than a finding. And the completion rate, because a large effect in the half of participants who finished is a different result from a large effect in everybody enrolled.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
InsuranceTom said:Agreed, and subgroup analyses deserve particular suspicion.
Can confirm the pattern InsuranceTom describes. Relative and absolute effects need reading together. A 20% relative reduction on a high baseline risk is a large absolute benefit; the same relative figure on a low baseline risk is a small one, and press summaries almost always quote the relative number because it is bigger.