Read the primary source rather than the write-up and the two do not agree, so here is what is actually in it.
The gallbladder signal is real and it is mostly the weight loss, not the drug. Rapid loss increases biliary cholesterol saturation and reduces gallbladder motility, which is the classic recipe for stones — the same effect appears after bariatric surgery and in very-low-calorie dieting, without any GLP-1 involved. Trial data shows a modest absolute increase in cholelithiasis, concentrated in faster losers.
Where I think it is weakest: the subgroup findings are the part I trust least — with enough subgroups something is always significant, and these were not all pre-registered.
The question I want answered is how much of the gallbladder signal is the drug and how much is simply the rate of weight loss, because the answer changes what you can do about it. Numbers rather than impressions, if you have them.
Note on sourcing:
Figures above are from the primary publication rather than the press summary. If a number here disagrees with one you have, post yours and we will work out which of us is reading a secondary source.