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ForumsOral GLP-1 AgonistsOrforglipron Phase 3 ATTAIN-1 topline — anyone have experience? Page 4

Orforglipron Phase 3 ATTAIN-1 topline — anyone have experience?

steve_okc Sat, Apr 26, 2025 at 11:16 AM 30 replies 1,800 viewsPage 4 of 6
Dr.RheumBOS
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May 1, 2025 at 3:57 AM#16

Adding the clinical framing, because it changes how the question reads. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.

5 3pam_stl, wei_SG, cory_ATX and 2 others
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gary_naperville
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May 1, 2025 at 3:19 PM#17
Dr.PathRoch said:
One practical note: write down what you did and when, before you need it.

Correct as far as it goes. The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.

Worth separating that from the trial evidence, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

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NeuroNate
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May 2, 2025 at 2:41 AM#18
Dr.PathRoch said:
One practical note: write down what you did and when, before you need it.

Thank you for spelling out the reasoning rather than just the conclusion. Printing the relevant bit and taking it with me.

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lisa_labSD
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May 2, 2025 at 2:03 PM#19

From the other side of the consultation, briefly. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

Worth separating that from the trial evidence, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

Last edited: May 2, 2025 at 5:03 PM
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mike_mod
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May 3, 2025 at 1:25 AM#20

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here. Tagging this one for the weekly digest.

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