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ForumsOff-TopicHas anyone dealt with showed my before photo to my hairdresser and she gasped? Page 2

Has anyone dealt with showed my before photo to my hairdresser and she gasped?

DerekSJ_a1c Tue, Sep 24, 2024 at 1:02 PM 10 replies 1,746 viewsPage 2 of 2
TrialNerd_Beth
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Sep 25, 2024 at 3:54 AM#6
LibrarianMeg said:
Neuroscience perspective on food noise: GLP-1 receptors are expressed throughout the CNS, with high density in the hypothalamic arcuate nucleus, area…

Alcohol relationship change with food noise: I used to drink 2 glasses of wine most nights. Since starting GLP-1 therapy, I have zero interest in alcohol. Haven't had a drink in 11 months.

The "food noise" reduction seems to extend to other reward-seeking behaviors, including alcohol. My liver enzymes have improved, my sleep is better, and I've saved roughly $197/month on alcohol. Triple win.

31 1RickReta_CO, PharmHunterJen, TomTeleRx and 28 others
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dan_philly
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Sep 25, 2024 at 9:47 AM#7
DerekSJ_a1c said:
The thing that changed for me was not hunger, it was that the constant background negotiation about food simply stopped, and I had not realised it was…

The GLP-1 and alcohol use disorder connection, relevant to food noise: observational data from Scandinavian registries shows reduced alcohol-related hospitalizations in GLP-1 agonist users[1].

The mechanism is plausible: GLP-1R is expressed in the mesolimbic reward pathway (VTA, nucleus accumbens). Agonism at these receptors may reduce the reinforcing properties of alcohol, similar to the reduction in "food noise."

RCTs for GLP-1 agonists in AUD are now underway. If positive, this would be a paradigm-shifting repurposing of existing medications.

References:
[1] Wang W, et al. Nat Med. 2024;30:574-584.
Last edited: Sep 25, 2024 at 12:47 PM
30 0AmyNC_wife, SkepticalSean, Dr.CardioMD and 27 others
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roxy_nash
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Sep 25, 2024 at 3:39 PM#8
TrialNerd_Beth said:
Alcohol relationship change with food noise: I used to drink 2 glasses of wine most nights.

Rebound hunger after missed dose of food noise: I missed my injection by 3 days due to a shipping delay and the hunger came ROARING back. Like a switch flipped. It was eye-opening to feel the difference.

This experience actually reinforced my understanding of what the medication does — it's not just "suppressing appetite," it's normalizing dysregulated hunger signaling. When the drug wears off, you feel the full force of what it was managing.

29 24tony_orlando, Dr.NephBHM_UK, kim_atl_prep and 26 others
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TinaHashiRN
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Sep 25, 2024 at 9:31 PM#9

A narrower follow-up, since the general answer is now clear:

Was that from a primary source or from a summary of one?

Last edited: Sep 26, 2024 at 3:31 AM
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DerekSJ_a1c
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Sep 27, 2024 at 1:42 AM#10
roxy_nash said:
Rebound hunger after missed dose of food noise: I missed my injection by 3 days due to a shipping delay and the hunger came ROARING back.

Phantom hunger vs real hunger on food noise: learning to distinguish between the two has been a revelation. Real hunger: gradual onset, physical stomach sensation, any food sounds good. Phantom hunger: sudden, emotionally triggered, specific food cravings, occurs right after eating.

The GLP-1 agonist suppresses real hunger beautifully. Phantom hunger still pops up but I can now recognize it for what it is — an emotional signal, not a physical need. Mindfulness training helped enormously with this distinction.

42 17AttorneyGrant, DebRD_ATL, KristenIndy and 39 others
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