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ForumsOral GLP-1 AgonistsOral sema absorption enhancer SNAC — looking for input Page 3

Oral sema absorption enhancer SNAC — looking for input

amy_econ_NJ Tue, Nov 4, 2025 at 6:39 AM 12 replies 1,235 viewsPage 3 of 3
fiona_glasgow
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Nov 6, 2025 at 2:06 AM#11
jim_asheville said:
The OASIS programme put 50mg oral in the same territory as 2.4mg injectable — around 15% mean weight loss — but it needed a dose 20 times larger to…

That reframing is the part I needed. Printing the relevant bit and taking it with me.

Last edited: Nov 6, 2025 at 7:06 AM
9 9TrialTracker_MD, JennaRN, LabKate and 6 others
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Dr.BariatricHTX
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Nov 6, 2025 at 7:19 AM#12

From the other side of the consultation, briefly. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.

8 8pete_RVA, CarlaRPh_TPA, steph_laguna and 5 others
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Dr.GastroMayo
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Nov 6, 2025 at 12:32 PM#13
Dr.ReproEndo said:
Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.

7 7COA_Karl, MikeFit_NJ, InsuranceTom and 4 others
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DataDave
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Nov 6, 2025 at 5:45 PM#14

The figures, for anyone assembling their own picture. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

Ask again with the specifics and you will get a better answer than this one.

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Admin
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Nov 6, 2025 at 10:58 PM#15

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. No action needed from anybody.

Last edited: Nov 7, 2025 at 2:58 AM
5 5PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 2 others
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