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ForumsMetabolic Health & DiabetesSURPASS-CVOT: tirzepatide cardiovascular outcomes trial design — anyone have experience? Page 4

SURPASS-CVOT: tirzepatide cardiovascular outcomes trial design — anyone have experience?

MeganSA_TX Tue, Jan 9, 2024 at 10:31 AM 18 replies 2,325 viewsPage 4 of 4
james_edin
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Jan 17, 2024 at 4:59 AM#16

From the other side of the consultation, briefly. Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third retelling.

Happy to go further on any of that.

Last edited: Jan 17, 2024 at 6:59 AM
25 0mona_PHX, andrew_nyc, Dr.EndoEP and 22 others
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PharmacoVig_BOS
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Jan 18, 2024 at 11:20 AM#17

Adding the clinical framing, because it changes how the question reads. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.

I would rather be corrected than agreed with, if it comes to it.

24 24Dr.GutHealth, amsterdam_pete, LondonLisa and 21 others
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DoseLogDan
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Jan 19, 2024 at 5:41 PM#18
PharmacoVig_BOS said:
The useful move here is to separate what is established from what is widely repeated.

This matches mine closely enough to be worth saying so out loud.

Last edited: Jan 19, 2024 at 6:41 PM
23 23mel_PDX, Dr.AddMedPHL, newstart_MO and 20 others
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Dr.BariatricHTX
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Jan 21, 2024 at 12:03 AM#19
PharmacoVig_BOS said:
The useful move here is to separate what is established from what is widely repeated.

Coming at PharmacoVig_BOS’s question from a different direction. It helps to say which part of this you are uncertain about. A precise question gets a precise answer; a general one gets everybody’s favourite anecdote.

Worth separating that from cardiovascular outcomes, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

22 22stefan_berlin, Dr.EM_Chicago, pete_RVA and 19 others
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Admin
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Jan 22, 2024 at 6:26 AM#20

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. No action needed from anybody.

50 0PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 47 others
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