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ForumsMetabolic Health & DiabetesPrediabetes reversal on GLP-1 — what worked for you?

Prediabetes reversal on GLP-1 — what worked for you?

MariaRD Thu, May 30, 2024 at 8:51 AM 47 replies 2,239 viewsPage 1 of 10
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MariaRD
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May 30, 2024 at 8:51 AM#1

A1C went from 7.4 to 5.6 over nine months and my prescriber was more interested in the fasting insulin, which I did not expect.

What I am after is why A1C lags the way it does, and what to look at in the meantime if you want to know sooner.

I have searched first, so if this is covered somewhere point me at it and I will read it.

50 20Dr.NutriCornell, pam_stl, wei_SG and 47 others
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VendorMark
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May 30, 2024 at 9:18 AM#2
MariaRD said:
A1C went from 7.4 to 5.6 over nine months and my prescriber was more interested in the fasting insulin, which I did not expect.

PCOS success story with glycaemic control: as someone with polycystic ovary syndrome, this medication has been transformative beyond weight loss.

After 9 months: periods became regular for the first time in ever, testosterone levels normalized, acne cleared significantly, and — unexpectedly — my hormonal symptoms have almost completely resolved.

GLP-1 agonists address the insulin resistance at the root of PCOS. For PCOS patients, this isn't "just" a weight loss drug — it's treating our underlying metabolic dysfunction.

Last edited: May 30, 2024 at 11:18 AM
49 19KristenIndy, MarkLI_maint, Dr.PeteFamMed and 46 others
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HPLC_Greg
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May 30, 2024 at 9:45 AM#3
VendorMark said:
PCOS success story with glycaemic control: as someone with polycystic ovary syndrome, this medication has been transformative beyond weight loss.

Complete metabolic panel trending on glycaemic control — sharing because comprehensive data helps everyone:

TestBaselineMonth 3Month 6Month 12
Glucose (fasting)1311019185
Insulin (fasting)2715115
HOMA-IR5.53.71.91.5
Uric Acid8.47.15.85.2

The insulin resistance improvement (HOMA-IR) is what my endo focuses on most. Going from 5.5 to near 1.0 is a metabolic transformation.

48 18RetaRick_CA, JenPlateau, SallyK_inj and 45 others
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ChrisMacros
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May 30, 2024 at 10:12 AM#4
MariaRD said:
A1C went from 7.4 to 5.6 over nine months and my prescriber was more interested in the fasting insulin, which I did not expect.

Same experience, arrived at from the opposite direction. Posting only so the count is not one.

Last edited: May 30, 2024 at 1:12 PM
47 17LibrarianMeg, bri_stats, pete_manc_UK and 44 others
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ingrid_STO
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May 30, 2024 at 12:37 PM#5

Adding the clinical framing, because it changes how the question reads.

Insulin sensitivity test (HOMA-IR) on glycaemic control — arguably the most important metabolic marker most people aren't tracking:

HOMA-IR = (fasting insulin × fasting glucose) ÷ 405

My numbers: Baseline HOMA-IR = 5.8 (insulin resistant) → Current = 1.2 (insulin sensitive)

Anything above 2.0 indicates insulin resistance. The goal is below 1.5. GLP-1 agonists address the root metabolic dysfunction, not just the symptoms. This is why they work so much better than calorie restriction alone.

Last edited: May 30, 2024 at 3:37 PM
46 16WendyG_ATL, SaraMom3, Dr.MetabolicMD and 43 others
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