From the other side of the consultation, briefly. Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third retelling.
Ask again with the specifics and you will get a better answer than this one.
FDA_TrackerJim said:The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…
Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.
FDA_TrackerJim said:The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…
This is exactly what I could not find anywhere else. Sending this to two other people who asked me the same thing last week.
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View ResultsAdding the clinical framing, because it changes how the question reads. It helps to say which part of this you are uncertain about. A precise question gets a precise answer; a general one gets everybody’s favourite anecdote.
Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. No action needed from anybody.