Adding the clinical framing, because it changes how the question reads. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
Clinical perspective, offered as context rather than as advice. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.
newstart_MO said:If two explanations both fit, the useful question is which one predicts something the other does not.
Mine went the same way, slower. Nothing to add that would improve it.
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Shop Reference Standardsnewstart_MO said:If two explanations both fit, the useful question is which one predicts something the other does not.
Coming at newstart_MO’s question from a different direction. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.
Happy to go further on any of that.