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ForumsPharmacology & MechanismsBiased agonism at GLP-1R — need advice Page 3

Biased agonism at GLP-1R — need advice

kevin_tulsa Thu, Feb 22, 2024 at 12:00 AM 12 replies 2,101 viewsPage 3 of 3
Dr.NutriCornell
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Feb 25, 2024 at 9:53 AM#11
paige_pharma said:
I want to add the drug interaction perspective on the pharmacology.

That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.

20 20emily_PDX, Dr.SleepRoch, laura_annarbor and 17 others
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carlos_SATX
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Feb 25, 2024 at 11:50 PM#12
rachel_ABQ said:
The mechanism is more central than most summaries suggest.

Thank you for spelling out the reasoning rather than just the conclusion. Adding it to my notes with a link back to this thread.

19 19FranDenver, Dr.BariatricHTX, LindaRN_retired and 16 others
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hans_munich
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Feb 26, 2024 at 1:47 PM#13
paige_pharma said:
I want to add the drug interaction perspective on the pharmacology.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I think the framing smuggles in the conclusion. Ask it the other way round and the obvious answer reverses, which usually means the question is doing the work.

18 18Dr.LipidDallas, alex_tucson, kevin_tulsa and 15 others
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Dr.PulmRoch
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Feb 27, 2024 at 3:45 AM#14

One concrete data point for the thread. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

17 17DebRD_ATL, KristenIndy, MarkLI_maint and 14 others
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mike_mod
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Feb 27, 2024 at 5:43 PM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out. Report rather than reply if it drifts again.

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