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ForumsPharmacology & MechanismsGLP-1R desensitization — looking for input Page 4

GLP-1R desensitization — looking for input

JakeBK_lifts Thu, Mar 7, 2024 at 9:07 AM 16 replies 2,188 viewsPage 4 of 4
claudia_zurich
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Mar 8, 2024 at 2:15 PM#16
pete_nash said:
Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

Second this. Nothing to add that would improve it.

49 24emma_london, tammy_FL, Dr.LipidDallas and 46 others
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newstart_MO
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Mar 8, 2024 at 5:41 PM#17

Adding the clinical framing, because it changes how the question reads. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.

48 23LibrarianMeg, bri_stats, pete_manc_UK and 45 others
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bbq_ray_KC
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Mar 8, 2024 at 9:07 PM#18
newstart_MO said:
Worth answering the question that was asked rather than the one behind it.

Can confirm. Same sequence, different timescale.

47 22InsuranceTom, WendyG_ATL, SaraMom3 and 44 others
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SarahChen_PharmD
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Mar 9, 2024 at 12:33 AM#19
newstart_MO said:
Worth answering the question that was asked rather than the one behind it.

There is a second half to this that has not been said yet. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

46 21TinaHashiRN, robert_kc, dan_philly and 43 others
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Admin
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Mar 9, 2024 at 3:59 AM#20

Moderator note: a couple of off-topic posts removed. Report rather than reply if it drifts again.

Last edited: Mar 9, 2024 at 7:59 AM
24 24PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 21 others
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