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ForumsOral GLP-1 AgonistsDanuglipron dose optimization — 12 month update Page 4

Danuglipron dose optimization — 12 month update

Dr.MetabolicMD Sat, Mar 14, 2026 at 8:45 PM 34 replies 1,534 viewsPage 4 of 7
TrialTracker_MD
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Mar 21, 2026 at 2:02 PM#16

From the other side of the consultation, briefly. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

38 13Dr.EM_Chicago, pete_RVA, CarlaRPh_TPA and 35 others
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raj_cambridge
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Mar 22, 2026 at 4:28 PM#17

Adding the numbers, since they settle part of this. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

Last edited: Mar 22, 2026 at 5:28 PM
37 12DoseLogDan, SleepFixSam, PurityPaulOR and 34 others
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traveltech_sara
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Mar 23, 2026 at 6:54 PM#18

A narrower follow-up, since the general answer is now clear:

How would you tell the difference between that and the alternative explanation?

36 11wanda_boise, NurseAsh_DET, BenResearch_OR and 33 others
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pete_RVA
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Mar 24, 2026 at 9:18 PM#19
raj_cambridge said:
Say what you would expect to see if you were wrong, before you look.

I read this differently from raj_cambridge, on substance rather than tone. I would resist the confidence. Half of what this board was certain about two years ago has since been quietly dropped, and nobody went back to correct the threads.

Last edited: Mar 25, 2026 at 2:18 AM
35 10MikeNYC_runner and 32 others
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mike_mod
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Mar 25, 2026 at 11:43 PM#20

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Thread quality here is what the rules are for. Keep it up.

13 13PurityPaulOR, MaxMetOK, MounjBrad and 10 others
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