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ForumsOral GLP-1 AgonistsDanuglipron BID dosing — 12 month update Page 3

Danuglipron BID dosing — 12 month update

nick_SD_fit Thu, Apr 16, 2026 at 6:49 PM 24 replies 747 viewsPage 3 of 5
JennaRN
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Apr 20, 2026 at 11:39 AM#11
rachel_ABQ said:
It helps to say which part of this you are uncertain about.

Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

Last edited: Apr 20, 2026 at 12:39 PM
12 10Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 9 others
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steph_laguna
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Apr 21, 2026 at 10:24 AM#12
NurseKim_ATL said:
The absorption variability is real, but it partly averages out over weeks — the steady-state trough is less erratic than any single day would suggest.

Saving this. It is the first explanation that did not require me to already understand it. Sending this to two other people who asked me the same thing last week.

13 11GraceAZ_72, carl_compliance, DanielChem_CHI and 10 others
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MaxMetOK
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Apr 22, 2026 at 9:08 AM#13
rachel_ABQ said:
It helps to say which part of this you are uncertain about.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.

That is the short version; the long version is somebody else's post.

14 12DoseLogDan, SleepFixSam, PurityPaulOR and 11 others
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PharmacoVig_BOS
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Apr 23, 2026 at 7:52 AM#14

One concrete data point for the thread. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

Last edited: Apr 23, 2026 at 10:52 AM
15 13kate.chem, DataDave, Dr.GutHealth and 12 others
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mike_mod
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Apr 24, 2026 at 6:35 AM#15

Moderator note: a couple of off-topic posts removed. Carry on.

16 14PurityPaulOR, MaxMetOK, MounjBrad and 13 others
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