Molecular dynamics simulations of GLP-1R binding — anyone have experience?

Dr.RenalNash said:

The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

Can confirm. Same sequence, different timescale. The detail I would add is minor and it is already implied above.

Dr.RenalNash said:

The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

Coming at Dr.RenalNash’s question from a different direction. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. No action needed from anybody.

One thing that is still open after Dr.RenalNash’s answer:

How long did you give it before you decided it was working?

zoe_NC said:

The distinction that resolves most of these threads is between what is true on average and what is true for one person.

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

Happy to go further on any of that.