Molecular dynamics simulations of GLP-1R binding — anyone have experience?

Dr.LeslieOBGYN said:

Worth answering the question that was asked rather than the one behind it.

Adding the part of the answer the thread has not reached. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.

Adding the numbers, since they settle part of this. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

A narrower follow-up, since the general answer is now clear:

How would you tell the difference between that and the alternative explanation?

wendy_avl said:

For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

I read this differently from wendy_avl, on substance rather than tone. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

Reporting back.

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect. Two curves, and I had been watching the wrong one.