TrialTracker_MD said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.
stefan_berlin said:The pharmacokinetics explain nearly every practical question asked here.
Thank you — that is the clearest version of this I have read, and I have read a lot of them. I will report back once I have actually tried it.
TrialTracker_MD said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.
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View ResultsThe figures, for anyone assembling their own picture. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.