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ForumsPharmacology & MechanismsReceptor internalization and recycling — my results so far Page 3

Receptor internalization and recycling — my results so far

SleepFixSam Sun, Aug 4, 2024 at 8:16 AM 18 replies 1,913 viewsPage 3 of 4
HPLC_Greg
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Aug 7, 2024 at 12:31 AM#11
anna.melb_AU said:
Semaglutide structural biology relevant to the pharmacology: semaglutide is a 31-amino acid peptide with 94% homology to native GLP-1(7-36).

Agreed on the substance. I would put less weight on the timescale, because two months of anything is not enough to distinguish a trend from a wobble.

27 0SallyK_inj, CryptoCarl, MariaRD and 24 others
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carlos_SATX
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Aug 8, 2024 at 2:52 AM#12
maya_sedona said:
The pharmacokinetics explain nearly every practical question asked here.

Bookmarking. The distinction being drawn above is the one nobody else makes.

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sophie_paris
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Aug 9, 2024 at 5:12 AM#13
anna.melb_AU said:
Semaglutide structural biology relevant to the pharmacology: semaglutide is a 31-amino acid peptide with 94% homology to native GLP-1(7-36).

Pushing back on anna.melb_AU here. The counter-case has not been addressed. Somebody upthread described the situation that does not fit, and the thread moved on rather than engaging with it, which is the failure mode this board is supposed to avoid.

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DoseLogDan
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Aug 10, 2024 at 7:32 AM#14

One concrete data point for the thread. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

Last edited: Aug 10, 2024 at 8:32 AM
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Admin
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Aug 11, 2024 at 9:51 AM#15

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part.

Last edited: Aug 11, 2024 at 1:51 PM
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