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ForumsMetabolic Health & DiabetesPrediabetes reversal on GLP-1 — my results so far

Prediabetes reversal on GLP-1 — my results so far

KarenAZ_mom Wed, Mar 5, 2025 at 2:11 PM 16 replies 1,721 viewsPage 1 of 4
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KarenAZ_mom
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Scottsdale, AZ
Mar 5, 2025 at 2:11 PM#1

A1C went from 7.4 to 5.6 over nine months and my prescriber was more interested in the fasting insulin, which I did not expect.

Because it is glucose-dependent, this class carries a low intrinsic hypoglycaemia risk on its own — the risk arrives when it is combined with insulin or a sulfonylurea, which usually need reducing.

What I am trying to establish is why A1C lags the way it does, and what to look at in the meantime if you want to know sooner.

Happy to be told the question itself is wrong.

26 21anna.melb_AU, mark_tokyo, hans_munich and 23 others
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amsterdam_pete
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Mar 5, 2025 at 2:44 PM#2
KarenAZ_mom said:
A1C went from 7.4 to 5.6 over nine months and my prescriber was more interested in the fasting insulin, which I did not expect.

Complete metabolic panel trending on glycaemic control — sharing because comprehensive data helps everyone:

TestBaselineMonth 3Month 6Month 12
Glucose (fasting)1171038987
Insulin (fasting)231797
HOMA-IR5.53.31.71.1
Uric Acid8.06.75.64.8

The insulin resistance improvement (HOMA-IR) is what my endo focuses on most. Going from 5.5 to near 1.0 is a metabolic transformation.

25 20ZaraB_AL, JakeSmashed95, NauseaFreeNow and 22 others
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rachel_ABQ
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Mar 5, 2025 at 3:17 PM#3
amsterdam_pete said:
Complete metabolic panel trending on glycaemic control — sharing because comprehensive data helps everyone: Test Baseline Month 3 Month 6 Month 12…

My labs after 9 months on glycaemic control: A1C 5.3%, fasting glucose 93 mg/dL, fasting insulin 4 uIU/mL. My endo says these are "textbook perfect."

For context, my baseline A1C was 8.1% and fasting glucose was 128 mg/dL. The improvement has been dramatic and consistent.

24 19AmyNC_wife, SkepticalSean, Dr.CardioMD and 21 others
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AmyNC_wife
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Mar 5, 2025 at 3:50 PM#4
KarenAZ_mom said:
A1C went from 7.4 to 5.6 over nine months and my prescriber was more interested in the fasting insulin, which I did not expect.

Same pattern here, and in the same order. The detail I would add is minor and it is already implied above.

Last edited: Mar 5, 2025 at 4:50 PM
23 18Dr.NateNeph, PharmD_Rodriguez, julia.endo and 20 others
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SleepDoc_PDX
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Portland, OR
Mar 5, 2025 at 6:54 PM#5

Adding the clinical framing, because it changes how the question reads.

PCOS success story with glycaemic control: as someone with polycystic ovary syndrome, this medication has been transformative beyond weight loss.

After 11 months: periods became regular for the first time in a decade, testosterone levels normalized, acne cleared significantly, and — unexpectedly — my fertility specialist is optimistic about future conception.

GLP-1 agonists address the insulin resistance at the root of PCOS. For PCOS patients, this isn't "just" a weight loss drug — it's treating our underlying metabolic dysfunction.

Last edited: Mar 5, 2025 at 9:54 PM
22 17mel_PDX, Dr.AddMedPHL, newstart_MO and 19 others
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