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ForumsPharmacology & MechanismsSemaglutide fatty acid sidechain — 12 month update Page 7

Semaglutide fatty acid sidechain — 12 month update

SaraMom3 Wed, Sep 11, 2024 at 3:09 PM 36 replies 2,367 viewsPage 7 of 8
Dr.PulmRoch
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Sep 25, 2024 at 2:07 AM#31

From the other side of the consultation, briefly. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

Happy to go further on any of that.

Last edited: Sep 25, 2024 at 3:07 AM
6 4rachel_ABQ, traveltech_sara, AttorneyGrant and 3 others
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jason_paloalto
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Sep 25, 2024 at 2:45 PM#32
Dr.PulmRoch said:
If two explanations both fit, the useful question is which one predicts something the other does not.

Same experience, arrived at from the opposite direction.

7 5Dr.PathRoch, mona_PHX, andrew_nyc and 4 others
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laura_annarbor
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Sep 26, 2024 at 3:23 AM#33
Dr.PulmRoch said:
If two explanations both fit, the useful question is which one predicts something the other does not.

Adding the part of the answer the thread has not reached. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

Last edited: Sep 26, 2024 at 5:23 AM
8 6Dr.SleepRoch, laura_annarbor, JenMemphis and 5 others
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kate.chem
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Sep 26, 2024 at 4:00 PM#34

Adding the numbers, since they settle part of this. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

9 7jennifer_SEA, tyler_CSCS, VanRx_Mike and 6 others
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DoseLogDan
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Sep 27, 2024 at 4:37 AM#35

One thing that is still open after Dr.PulmRoch’s answer:

What the dose-response curve actually looks like above 1.7mg, because the trial means hide how few people account for the extra loss?

10 8carlos_SATX, sophie_paris, mel_PDX and 7 others
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