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ForumsPharmacology & MechanismscAMP signaling cascade from GLP-1R activation — need advice Page 3

cAMP signaling cascade from GLP-1R activation — need advice

LondonLisa Tue, Sep 24, 2024 at 3:28 AM 13 replies 1,952 viewsPage 3 of 3
CarlaRPh_TPA
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Sep 25, 2024 at 4:42 PM#11
Dr.SportsMedIN said:
Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…

That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.

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wei_SG
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Sep 26, 2024 at 2:21 PM#12
carlos_SATX said:
The mechanism is more central than most summaries suggest.

Genuinely useful, thank you. I had the facts and not the framework. I will report back once I have actually tried it.

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mike_nyc
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Sep 27, 2024 at 12:00 PM#13
Dr.SportsMedIN said:
Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…

Pushing back on Dr.SportsMedIN here. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

1 24Dr.EM_Chicago
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DoseLogDan
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Sep 28, 2024 at 9:38 AM#14

The figures, for anyone assembling their own picture. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

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mike_mod
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Sep 29, 2024 at 7:16 AM#15

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. Tagging this one for the weekly digest.

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