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ForumsPharmacology & MechanismsBiased agonism at GLP-1R — 12 month update Page 10

Biased agonism at GLP-1R — 12 month update

pam_columbus Tue, Dec 17, 2024 at 6:06 AM 52 replies 2,746 viewsPage 10 of 11
PharmacoVig_BOS
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Dec 19, 2025 at 11:06 AM#46
SleepDoc_PDX said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Agreed on the substance. I would put less weight on the timescale, because two months of anything is not enough to distinguish a trend from a wobble.

49 22amsterdam_pete, LondonLisa, mike_nyc and 46 others
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pam_columbus
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Jan 1, 2026 at 1:31 PM#47

Reporting back.

Reporting back with a partial result, because a partial result is still better than silence. Two of the three things suggested helped; I cannot separate them and I am not going to pretend otherwise.

50 23alex_tucson, kevin_tulsa, Dr.PainCLE and 47 others
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Dr.GutHealth
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Jan 14, 2026 at 3:48 PM#48

From the other side of the consultation, briefly. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

1 24jennifer_SEA
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pete_nash
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Jan 27, 2026 at 5:57 PM#49
Dr.GutHealth said:
The mechanism and the magnitude are separate questions.

This matches mine closely enough to be worth saying so out loud.

2 0SarahChen_PharmD, sarah.morrison
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AussieAnna
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Feb 9, 2026 at 7:59 PM#50
Dr.GutHealth said:
The mechanism and the magnitude are separate questions.

There is a second half to this that has not been said yet. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.

That is the short version; the long version is somebody else's post.

24 22pete_manc_UK, anna.melb_AU, mark_tokyo and 21 others
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