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ForumsOral GLP-1 AgonistsATTAIN-2: orforglipron in T2DM — glycemic endpoints Page 5

ATTAIN-2: orforglipron in T2DM — glycemic endpoints

TrialTracker_MD Mon, May 25, 2026 at 5:34 AM 23 replies 549 viewsPage 5 of 5
LarryQC_SD
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May 31, 2026 at 4:28 AM#21
Dr.NateNeph said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

2 0NurseKim_ATL, paul_denver
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nick_newbie
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Jun 2, 2026 at 2:14 AM#22
Dr.NateNeph said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Correct, and worth adding that it is reversible. Nothing being described here is a one-way door, which changes how cautious it is reasonable to be.

Last edited: Jun 2, 2026 at 5:14 AM
3 1dan_philly, MeganSA_TX, LarryQC_SD
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ChrisMacros
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Jun 4, 2026 at 12:01 AM#23
Dr.NateNeph said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

This is exactly what I could not find anywhere else. Sending this to two other people who asked me the same thing last week.

Last edited: Jun 4, 2026 at 3:01 AM
4 2HPLC_Greg, LibrarianMeg, bri_stats and 1 other
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hyun_seoul
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Jun 5, 2026 at 9:49 PM#24

Clinical perspective, offered as context rather than as advice. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

5 3BariatricNurseD, MASHdoc_SA, GenomicsKate and 2 others
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RetaRick_CA
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Jun 7, 2026 at 7:39 PM#25
hyun_seoul said:
If two explanations both fit, the useful question is which one predicts something the other does not.

This is my experience too, for whatever a second data point is worth. I had assumed I was the exception until I read this.

Last edited: Jun 7, 2026 at 8:39 PM
6 4MounjBrad, nick_newbie, DadBodDave and 3 others
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