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ForumsPharmacology & MechanismsSo the drug literally changes your brain?? That is wild — anyone have experience? Page 8

So the drug literally changes your brain?? That is wild — anyone have experience?

Dr.PulmRoch Fri, Jan 31, 2025 at 1:55 PM 49 replies 2,218 viewsPage 8 of 10
oliver_london
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May 22, 2025 at 9:15 PM#36
hank_denver said:
Practical: whatever you change, write down the date and the reason.

Bookmarking. The distinction being drawn above is the one nobody else makes. I will report back once I have actually tried it.

49 22Admin, Dr.Martinez, mike_mod and 46 others
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julia.endo
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May 29, 2025 at 2:33 AM#37

Clinical perspective, offered as context rather than as advice. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.

50 23mark_tokyo, hans_munich, jason_sac26 and 47 others
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nick_SD_fit
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Jun 4, 2025 at 7:48 AM#38
julia.endo said:
It helps to ask what evidence would change your mind before you look at any.

Same experience, arrived at from the opposite direction. I had assumed I was the exception until I read this.

Last edited: Jun 4, 2025 at 9:48 AM
1 24EndoResFellow
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labquiet_amy
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Jun 10, 2025 at 12:59 PM#39
julia.endo said:
It helps to ask what evidence would change your mind before you look at any.

There is a second half to this that has not been said yet. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

Last edited: Jun 10, 2025 at 2:59 PM
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anders_CPH
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Jun 16, 2025 at 6:07 PM#40

One concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

24 22ChrisMacros, KetoKyle, CanadaChris and 21 others
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