So the drug literally changes your brain?? That is wild — anyone have experience?

chris_chi24 said:

Semaglutide structural biology relevant to the pharmacology: semaglutide is a 31-amino acid peptide with 94% homology to native GLP-1(7-36).

Agreed on the substance. I would put less weight on the timescale, because two months of anything is not enough to distinguish a trend from a wobble.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

B12Beth said:

The mechanism is more central than most summaries suggest.

Thank you for spelling out the reasoning rather than just the conclusion. Printing the relevant bit and taking it with me.

chris_chi24 said:

Semaglutide structural biology relevant to the pharmacology: semaglutide is a 31-amino acid peptide with 94% homology to native GLP-1(7-36).

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

I would rather be corrected than agreed with, if it comes to it.

One concrete data point for the thread. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here. Thread quality here is what the rules are for. Keep it up.