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ForumsOral GLP-1 AgonistsSmall molecule vs peptide GLP-1 agonists — binding affinity comparison Page 4

Small molecule vs peptide GLP-1 agonists — binding affinity comparison

PeptideChemSF Sun, May 31, 2026 at 5:43 PM 16 replies 583 viewsPage 4 of 4
Dr.ObesityLA
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Jun 2, 2026 at 9:59 AM#16
Dr.RheumBOS said:
The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

This is my experience too, for whatever a second data point is worth. I had assumed I was the exception until I read this.

9 7zoe_NC, Dr.ObesityLA, NurseKim_ATL and 6 others
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Dr.PainCLE
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Jun 2, 2026 at 3:39 PM#17

A narrower follow-up, since the general answer is now clear:

Was that from a primary source or from a summary of one?

10 8tane_welly, Dr.PathRoch, mona_PHX and 7 others
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dan_philly
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Jun 2, 2026 at 9:18 PM#18
stefan_berlin said:
Practical: whatever you change, write down the date and the reason.

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

Happy to go further on any of that.

Last edited: Jun 3, 2026 at 12:18 AM
11 9SkepticalSean, Dr.CardioMD, EndoResFellow and 8 others
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HealthEcon_DC
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Jun 3, 2026 at 2:57 AM#19
stefan_berlin said:
Practical: whatever you change, write down the date and the reason.

No disagreement, though the timescale matters more than the mechanism here. Most of what looks like a difference in kind turns out to be a difference in how long somebody waited.

12 10TirzTom, TrialTracker_MD, JennaRN and 9 others
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Admin
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Jun 3, 2026 at 8:36 AM#20

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. Tagging this one for the weekly digest.

Last edited: Jun 3, 2026 at 12:36 PM
34 7PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 31 others
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