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ForumsMetabolic Health & DiabetesSURPASS-CVOT: tirzepatide cardiovascular outcomes trial design — looking for input Page 4

SURPASS-CVOT: tirzepatide cardiovascular outcomes trial design — looking for input

Admin Sat, Jul 12, 2025 at 7:09 AM 40 replies 1,896 viewsPage 4 of 8
PeptideChemSF
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Jul 30, 2025 at 11:08 PM#16

Clinical perspective, offered as context rather than as advice. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.

26 24steve_okc, dave_SLC, FDA_TrackerJim and 23 others
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TrialTracker_MD
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Aug 2, 2025 at 10:03 PM#17

Adding the numbers, since they settle part of this. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

27 0stefan_berlin, Dr.EM_Chicago, pete_RVA and 24 others
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FDA_TrackerJim
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Aug 5, 2025 at 8:57 PM#18

Following on from BethLabQueen — and this may be the naive question:

How much of the SELECT benefit is plausibly independent of the weight loss, and whether that distinction changes anything practical?

28 1MikeNYC_runner and 25 others
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Dr.PulmRoch
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Aug 8, 2025 at 7:49 PM#19
TrialTracker_MD said:
One practical note: write down what you did and when, before you need it.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

Last edited: Aug 8, 2025 at 8:49 PM
29 2DebRD_ATL, KristenIndy, MarkLI_maint and 26 others
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ricardo_MIA
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Aug 11, 2025 at 6:40 PM#20

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Report rather than reply if it drifts again.

1 24ChrisMacros
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