hyun_seoul said:The useful move here is to separate what is established from what is widely repeated.
That holds for the injectable. The oral formulation has different absorption behaviour and the dose numbers are not interchangeable, which is worth saying out loud because people quote them as if they were.
I would rather be corrected than agreed with, if it comes to it.
B12Beth said:Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak.
Thank you for spelling out the reasoning rather than just the conclusion. I will report back once I have actually tried it.
hyun_seoul said:The useful move here is to separate what is established from what is widely repeated.
Pushing back on hyun_seoul here. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
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View ResultsOne concrete data point for the thread. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.
Moderator note: a couple of off-topic posts removed. Thread quality here is what the rules are for. Keep it up.