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ForumsPharmacology & MechanismsPeptide degradation pathways — my results so far Page 3

Peptide degradation pathways — my results so far

MeganSA_TX Tue, May 6, 2025 at 6:48 AM 15 replies 1,663 viewsPage 3 of 3
RetaRick_CA
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May 9, 2025 at 11:41 PM#11
Dr.SportsMedIN said:
Amycretin (AMY/GLP-1 dual agonist) emerging data relevant to the pharmacology: Phase 1 showed -13.1% body weight at only 12 weeks, the fastest…

Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.

Last edited: May 10, 2025 at 12:41 AM
2 0SkepticalSean, Dr.CardioMD
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zoe_NC
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May 12, 2025 at 4:46 PM#12
DanielChem_CHI said:
The pharmacokinetics explain nearly every practical question asked here.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Adding it to my notes with a link back to this thread.

3 1FranDenver, Dr.BariatricHTX, LindaRN_retired
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josh_phd_bmore
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May 15, 2025 at 9:49 AM#13
Dr.SportsMedIN said:
Amycretin (AMY/GLP-1 dual agonist) emerging data relevant to the pharmacology: Phase 1 showed -13.1% body weight at only 12 weeks, the fastest…

This is where I part company with the consensus forming above. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.

That is the short version; the long version is somebody else's post.

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anders_CPH
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May 18, 2025 at 2:51 AM#14

One concrete data point for the thread. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

Last edited: May 18, 2025 at 6:51 AM
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Admin
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May 20, 2025 at 7:52 PM#15

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. Tagging this one for the weekly digest.

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