cAMP signaling cascade from GLP-1R activation — 12 month update

hyun_seoul said:

Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…

Right, and the exception is worth naming rather than left implied, because the exception is where people get into trouble.

MeganSA_TX said:

The pharmacokinetics explain nearly every practical question asked here.

Thank you for spelling out the reasoning rather than just the conclusion. Adding it to my notes with a link back to this thread.

hyun_seoul said:

Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…

I read this differently from hyun_seoul, on substance rather than tone. I would resist the confidence. Half of what this board was certain about two years ago has since been quietly dropped, and nobody went back to correct the threads.

One concrete data point for the thread. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Tagging this one for the weekly digest.