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ForumsPharmacology & MechanismsHas anyone dealt with structure-activity relationships of glp-1 analogs? Page 5

Has anyone dealt with structure-activity relationships of glp-1 analogs?

A1cHero_PHX Wed, Jul 2, 2025 at 7:41 PM 27 replies 1,773 viewsPage 5 of 6
PharmD_Rodriguez
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Jul 10, 2025 at 7:11 PM#21
TirzTom said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Right, and the exception is worth naming rather than left implied, because the exception is where people get into trouble.

49 22paul_denver, TinaHashiRN, robert_kc and 46 others
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TrialNerd_Beth
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Jul 13, 2025 at 8:46 AM#22
TirzTom said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Thank you for spelling out the reasoning rather than just the conclusion. Taking it to my next appointment.

Last edited: Jul 13, 2025 at 12:46 PM
50 23PharmHunterJen, TomTeleRx, DoseLogDan and 47 others
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rachel_ABQ
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Jul 15, 2025 at 10:20 PM#23

From the other side of the consultation, briefly. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

1 24AmyNC_wife
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LarryQC_SD
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Jul 18, 2025 at 11:52 AM#24
rachel_ABQ said:
The version of this that has an answer is narrower than the version being asked.

This matches mine closely enough to be worth saying so out loud. The detail I would add is minor and it is already implied above.

2 0robert_kc, dan_philly
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mike_mealprep
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Jul 21, 2025 at 1:23 AM#25
rachel_ABQ said:
The version of this that has an answer is narrower than the version being asked.

There is a second half to this that has not been said yet. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

3 1sophie_paris, mel_PDX, Dr.AddMedPHL
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