NurseKim_ATL said:The pharmacokinetics explain nearly every practical question asked here.
Agreed, and the adaptation point cuts both ways: tachyphylaxis to gastric emptying is why tolerability improves, and it is also why people who were relying on physical fullness feel the effect fade while the appetite effect is still working.
paul_denver said:True, though the ladder is longer and that is not a neutral detail — six dose steps means six opportunities to stall on the way up, and plenty of…
Saving this. It is the first explanation that did not require me to already understand it. Sending this to two other people who asked me the same thing last week.
NurseKim_ATL said:The pharmacokinetics explain nearly every practical question asked here.
Pushing back on NurseKim_ATL here. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.
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View ResultsOne concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.