Adiponectin and leptin changes on GLP-1 therapy — what worked for you?

Dr.SurgeonPGH said:

labquiet_amy said: ...mental health should only be used alongside therapy...

When to call your doctor about mental health side effects — a reference I wish I'd had:

Call immediately:

• Severe abdominal pain (could be pancreatitis)
• Vision changes (thyroid concern)
• Lump in neck (thyroid nodule)
• Severe vomiting/can't keep fluids down for 24h+

Schedule an appointment:

• Persistent nausea beyond 4 weeks
• Significant hair loss
• Mood changes or depression
• Gallbladder symptoms (RUQ pain after eating)

emily_PDX said:

Positive side effects of mental health that surprised me: Clearer skin — inflammation reduction improved my rosacea Better sleep — weight loss…

Thank you for spelling out the reasoning rather than just the conclusion. I will report back once I have actually tried it.

Dr.SurgeonPGH said:

labquiet_amy said: ...mental health should only be used alongside therapy...

Before/after narrative for mental health — one year in:

Before (278 lbs): Winded climbing stairs, chronic back pain, pre-diabetic, on 3 medications, dreaded mirrors, avoided photos, social anxiety about my weight.

After (198 lbs): Run 3 miles regularly, pain-free, A1C normal, down to 1 medication, bought a swimsuit for the first time in a decade, actually enjoy being photographed.

Total weight lost: 78 lbs. Total life gained: immeasurable. This isn't just about weight — it's about reclaiming your identity.

bri_stats said:

The weight came off and the harder part started, which is not what any of the material I read had prepared me for.

Recovering from an eating disorder and using mental health: this is a complex situation and I want to be transparent about it.

I have a history of binge eating disorder. My psychiatrist, therapist, and prescribing doctor all collaborate on my care. The GLP-1 agonist has actually been therapeutic — it removes the biological urgency of binge impulses without relying on restriction.

This is NOT appropriate for all ED patients. Anorexia, bulimia, and restrictive EDs require different approaches. But for BED specifically, the evidence and my personal experience are positive. Always involve your mental health team.

Moderator note: a couple of off-topic posts removed. Tagging this one for the weekly digest.