Has anyone dealt with ⚠ peptidemeter exposed: some vendors scoring e grade on basic peptides?

Adding the clinical framing, because it changes how the question reads.

Mass spectrometry confirmation for certificates of analysis: beyond HPLC purity, mass spec tells you the molecule's exact molecular weight. This confirms identity — not just purity.

Why this matters: HPLC can show you a "pure" compound, but if it's pure of the WRONG compound, purity is meaningless. Mass spec at m/z 4113.58 Da confirms it's actually semaglutide. My Janoshik report includes both HPLC and mass spec.

If your testing provider only offers HPLC, consider upgrading to include mass spec for at least your first batch from a new vendor.

Dr.NateNeph said:

Third-party testing services for certificates of analysis besides Janoshik: Janoshik: Gold standard for peptide community, ~$137, 10-14 day turnaround…

Community-verified vendors for certificates of analysis: I maintain a spreadsheet of Janoshik-verified test results submitted by community members. Across 54 submitted tests:

• 82% tested at ≥98% purity
• 12% tested at 95-98% purity
• 6% tested at <95% purity (concerning)

The vendors with consistently high purity results are listed in the Vendor Directory. We update monthly based on new community submissions.

A narrower follow-up, since the general answer is now clear:

What a vetting checklist should actually contain, as opposed to a list of things that are easy to fake?

Dr.PathRoch said:

Community-verified vendors for certificates of analysis: I maintain a spreadsheet of Janoshik-verified test results submitted by community members.

My HPLC chromatogram analysis for certificates of analysis — I sent my batch to Janoshik and here's what the results showed:

Main peak retention time: 14.3 minutes (consistent with semaglutide reference standard)
Peak purity: 99.0%
Related substances: 0.8% (single impurity at 8.3 minutes — likely a synthesis intermediate)
Mass spec: m/z 4113.58 (matches expected molecular weight)

This is a clean result. The mass spec confirmation is particularly important — it proves the molecule is actually semaglutide and not a substitution.

Moderator note: the sourcing question belongs in the vendor section and has been split out. No action needed from anybody.