Clinical perspective, offered as context rather than as advice. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.
A narrower follow-up, since the general answer is now clear:
How much of the between-person variation is pharmacokinetic and how much is just adherence measured badly?
BariatricNurseD said:It is worth asking what the claim would look like if it were false.
Pushing back on BariatricNurseD here. Steady state is the thing most people miss. The terminal half-life is about a week, so every dose step takes four to five weeks to fully express itself. Judging a step at day ten is judging the ascent, not the plateau, and it is the single commonest reason people escalate before they needed to.
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Shop Reference StandardsBariatricNurseD said:It is worth asking what the claim would look like if it were false.
That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.
Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. Carry on.