Has anyone dealt with why does it stop working after a while for some people?

Dr.EndoIndy said:

There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Coming at Dr.EndoIndy’s question from a different direction. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

Adding the numbers, since they settle part of this. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

Correct me if the detail matters more than I have assumed.

A narrower follow-up, since the general answer is now clear:

How long did you give it before you decided it was working?

HPLC_Greg said:

Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Pushing back on HPLC_Greg here. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

Reporting back.

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect. Two curves, and I had been watching the wrong one.