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ForumsPharmacology & MechanismsBiased agonism at GLP-1R — my results so far Page 3

Biased agonism at GLP-1R — my results so far

nancy_portland Mon, May 4, 2026 at 2:29 AM 12 replies 520 viewsPage 3 of 3
Dr.ReproEndo
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May 7, 2026 at 3:03 AM#11
MASHdoc_SA said:
Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…

Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.

30 5mona_PHX, andrew_nyc, Dr.EndoEP and 27 others
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paul_denver
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May 9, 2026 at 10:56 PM#12
COA_Karl said:
The mechanism is more central than most summaries suggest.

Thank you for spelling out the reasoning rather than just the conclusion. Taking it to my next appointment.

29 4jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 26 others
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ingrid_STO
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May 12, 2026 at 6:51 PM#13
MASHdoc_SA said:
Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…

Worth saying that the confident version of this is more useful to the person writing it than to the person reading it.

I would rather be corrected than agreed with, if it comes to it.

Last edited: May 12, 2026 at 9:51 PM
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PeptideSynthNJ
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May 15, 2026 at 2:47 PM#14

Adding the numbers, since they settle part of this. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

Last edited: May 15, 2026 at 6:47 PM
27 2MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 24 others
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mike_mod
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May 18, 2026 at 10:45 AM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Report rather than reply if it drifts again.

26 1PurityPaulOR, MaxMetOK, MounjBrad and 23 others
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