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ForumsPharmacology & MechanismsGLP-1R desensitization — what worked for you? Page 3

GLP-1R desensitization — what worked for you?

traveltech_sara Thu, May 7, 2026 at 12:53 AM 11 replies 526 viewsPage 3 of 3
LipidDoc_ATL
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May 8, 2026 at 4:35 AM#11
GenomicsKate said:
Amycretin (AMY/GLP-1 dual agonist) emerging data relevant to the pharmacology: Phase 1 showed -13.1% body weight at only 12 weeks, the fastest…

True, with the qualification that this is a self-selected group. The people for whom it did not work post less, and that shapes everything we think we know.

14 14rachel_ABQ, traveltech_sara, AttorneyGrant and 11 others
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tyler_CSCS
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May 8, 2026 at 10:55 AM#12
amsterdam_pete said:
The pharmacokinetics explain nearly every practical question asked here.

That reframing is the part I needed. I will report back once I have actually tried it.

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PedsEndoPhilly
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May 8, 2026 at 5:15 PM#13
GenomicsKate said:
Amycretin (AMY/GLP-1 dual agonist) emerging data relevant to the pharmacology: Phase 1 showed -13.1% body weight at only 12 weeks, the fastest…

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I think the framing smuggles in the conclusion. Ask it the other way round and the obvious answer reverses, which usually means the question is doing the work.

Last edited: May 8, 2026 at 10:15 PM
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Dr.PulmRoch
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May 8, 2026 at 11:35 PM#14

Adding the numbers, since they settle part of this. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

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Admin
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May 9, 2026 at 5:56 AM#15

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here. No action needed from anybody.

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