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ForumsPharmacology & MechanismscAMP signaling cascade from GLP-1R activation — complete pathway map Page 3

cAMP signaling cascade from GLP-1R activation — complete pathway map

NeuroNate Thu, Jun 4, 2026 at 2:24 AM 14 replies 385 viewsPage 3 of 3
DadBodDave
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Jun 4, 2026 at 8:55 PM#11
paige_pharma said:
I want to add the drug interaction perspective on the pharmacology.

Saving this. It is the first explanation that did not require me to already understand it. Printing the relevant bit and taking it with me.

Last edited: Jun 4, 2026 at 11:55 PM
39 12laura_annarbor, JenMemphis, pat_auckland and 36 others
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Dr.PathRoch
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Jun 5, 2026 at 9:12 AM#12

Adding the clinical framing, because it changes how the question reads. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.

Last edited: Jun 5, 2026 at 3:12 PM
40 13InsuranceTom, WendyG_ATL, SaraMom3 and 37 others
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mike_nyc
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Jun 5, 2026 at 9:29 PM#13
Dr.KarenChen said:
Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…

Pushing back on Dr.KarenChen here. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

41 14Dr.EM_Chicago, pete_RVA, CarlaRPh_TPA and 38 others
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dave_SLC
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Jun 6, 2026 at 9:46 AM#14

The figures, for anyone assembling their own picture. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

42 15FranDenver, Dr.BariatricHTX, LindaRN_retired and 39 others
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mike_mod
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Jun 6, 2026 at 10:04 PM#15

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here.

Last edited: Jun 7, 2026 at 12:04 AM
43 16PurityPaulOR, MaxMetOK, MounjBrad and 40 others
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